Evaluation of Left Ventricular Ejection Fraction Using an Accelerated Cardiac Cine-MRI Sequence With Deep Learning-based Image Reconstructions

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire, Amiens

About this trial

Left ventricular hypertrophy (LVH) is a common condition that may result from hypertension, hypertrophic cardiomyopathy, aortic valve stenosis, or certain metabolic disorders. Cardiac imaging is essential for diagnosis, prognostic assessment, and quantification of cardiac function. While transthoracic echocardiography remains widely used, it is limited by acoustic window dependence and inter-observer variability. Cardiovascular Magnetic Resonance (CMR) imaging currently serves as the reference standard for measuring left ventricular ejection fraction (LVEF), cardiac volumes, and tissue characterization. However, conventional cine-CMR sequences require repeated breath-holds, which are often challenging for elderly or dyspneic patients, generating respiratory motion artifacts that compromise image quality. Accelerated cine-CMR sequences with deep learning-based image reconstructions offer a promising alternative by significantly reducing acquisition time while preserving image quality. This study aims to evaluate whether these accelerated cine-CMR sequences provide LVEF measurements concordant with conventional cine-CMR sequences, with potential to improve patient comfort and reduce examination time.

Eligibility criteria

Qualifiers

Patient referred for cardiac MRI as part of the assessment or follow-up of left ventricular hypertrophy

Age ≥ 18 years old

Ability of the subject to understand and express his consent

Affiliation to the social security scheme

Disqualifiers

Severe obesity (>140 kg) preventing the patient from entering the scanner bore, which has a diameter of less than 70 cm

Age ≥ 18 years old

Person under guardianship or curators, or deprived of liberty

Pregnant or breastfeeding woman

Trial design

Treatments tested in this trial

  • accelerated cardiac cine-MRI sequence

Treatment groups

No treatment groups listed