Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit

The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult intensive care unit (ICU) patients. The main questions it aims to answer are:

Can the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) predict successful extubation?

What is the prognostic value of other echocardiographic measures such as Mitral Annular Plane Systolic Excursion (MAPSE), E/e' ratio, E/A ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) in forecasting weaning outcomes?

Participants will:

Be adults receiving mechanical ventilation and scheduled for weaning

Undergo transthoracic echocardiography (TTE) within 2 hours after meeting weaning criteria

Have the following parameters measured: LVOT VTI, MAPSE, E/e', E/A, MDT, and Tei index

Be monitored for 24 hours post-extubation to determine if they remain off ventilatory support, including reintubation, non-invasive ventilation, or high-flow oxygen therapy

This study aims to provide a comprehensive understanding of how systolic, diastolic, and global cardiac functions influence extubation success, potentially improving ICU decision-making and reducing complications, length of stay, and healthcare costs.