About this trial
Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment. When these patients undergo a comprehensive evaluation at the time of invasive coronary angiography, occult coronary abnormalities are frequently found. We hope to learn the overall prevalence and presentation of these occult coronary abnormalities and its long term outcome in this patient population.
Eligibility criteria
Qualifiers
Patient referred for elective coronary angiography because of a reasonable clinical suspicion of coronary ischemia.
Presence of angina or an anginal equivalent (including chest, back, shoulder, arm, neck, jaw discomfort, or shortness of breath brought on by physical exertion, emotional stress, or certain times of day/month).
Disqualifiers
Asymptomatic (such as a pre-op cath)
Status-post heart transplant
Age <18
Renal insufficiency (creatinine >1.5)
Trial design
Treatments tested in this trial
- 30 cc blood draw
- Intravascular ultrasound (IVUS)
- Coronary pressure/flow wire testing
- Coronary pressure/flow testing: Acetycholine challenge
- Procedure: Coronary pressure/flow testing: Nitroglycerin challenge
- Procedure: Procedure: Coronary pressure/flow testing: Adenosine challenge