EValuation Of poLygenic Scores and CT imAging In Risk Factor Modification in Patients With diabEtes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorMonash University
About this trial
This study is a three-arm, parallel-group, randomised controlled trial evaluating the effect of using cardiac CT imaging or polygenic risk score in cardiovascular risk factor modification in patients with diabetes.
Eligibility criteria
Qualifiers
Age 40 years or older
Established diagnosis of T2DM
Having acceptable imaging quality as deemed by the VHI-AICL
Able to have a PRS calculated
Disqualifiers
Unable to provide written informed consent.
Unwilling to be followed for serial evaluation
Clinically manifest CV disease
Evidence of clinically significant coronary disease on CT that would preclude masking from participant's treating clinician for the duration of the study on the grounds of safety, including but not limited to, equal/greater than 50% in the left main coronary artery or equal/greater than 70% in any epicardial coronary artery
Trial design
Treatments tested in this trial
- CTCA results
- PRS results
Treatment groups
90 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov