Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorBoston Children's Hospital
About this trial
The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to:
1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and serum GABA and pro-inflammatory cytokine levels 2. Understand the correlation between GABA and inflammatory cytokines (and/or activated monocytes) and 3. Assess the correlation between thrombosis and monocyte activation in patients undergoing cardiac surgery under CPB and at risk of thrombosis.
Eligibility criteria
Qualifiers
Patients (all ages) undergoing complex cardiac surgical procedures with CPB.
Disqualifiers
undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent
patient in a moribund condition American Society of Anesthesiology (ASA 5) -patient with a hematological and/or oncological disease
Jehovah witnesses.
Trial design
Treatments tested in this trial
- Discarded blood samples
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov