Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCovenant Health Cancer Center
About this trial
This purpose of this study is to examine skin reactions (called radiation dermatitis) that occur during pencil beam scanning (PBS) proton therapy. The researchers will test a unique technique called "Spot Delete" to see if it can reduce skin reactions for head \& neck patients treated with PBS. The investigators will also use a special computer model to study how the energy of the proton beam (linear energy transfer) is related to these skin reactions. The study involves creating a treatment plan based on a CT scan, which helps guide the proton beam in the body.
Eligibility criteria
Qualifiers
The patient must consent to be in the study and must have signed an approved consent form conforming to federal and institutional guidelines.
Patients must be ≥ 18 years old.
Patient must have biopsy-proven squamous cell carcinoma, originating in the oral cavity, larynx, oropharynx, nasopharynx, or hypopharynx
Carcinoma of the neck of unknown primary site origin may be included if p16 positive
Disqualifiers
Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
Head and neck radiotherapy that does NOT include at least one cervical lymph node level (I, II, III, IV, or V) in the target volume.
Children
Women who are pregnant.
Trial design
Treatments tested in this trial
- Spot Delete
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov