EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorLiaquat University of Medical & Health Sciences

About this trial

Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing.

Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.

Eligibility criteria

Qualifiers

healthy volunteers

patients with oral submucous fibrosis

patients with biopsy proven oral cancer

Disqualifiers

patients with oral infection

Trial design

Treatments tested in this trial

  • saliva a a diagnostic tool for early detection of oral cancer

Treatment groups

1,000 Participants
are divided into 3 treatment groups

Locations

1

Map coordinates are unavailable for these locations. Locations are shown below instead.

Medical Research CenterRecruiting Jāmshoro, SinchPakistanPakistan

Sponsors and collaborators

Liaquat University of Medical & Health Sciences

Lead sponsor

Sindh Higher Education Commission

Collaborator