About this trial
Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing.
Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.
Eligibility criteria
Qualifiers
healthy volunteers
patients with oral submucous fibrosis
patients with biopsy proven oral cancer
Disqualifiers
patients with oral infection
Trial design
Treatments tested in this trial
- saliva a a diagnostic tool for early detection of oral cancer
Treatment groups
Locations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
Sponsors and collaborators
Liaquat University of Medical & Health Sciences
Lead sponsor
Sindh Higher Education Commission
Collaborator