Acne vulgaris is a common chronic inflammatory skin disorder that affects adolescents and young adults. Recent research has shown that lipid mediators, including ceramides and sphingolipids, play an important role in maintaining skin barrier function and inflammation.
This study aims to evaluate the serum levels of ceramide C16, ceramide C24, and sphingosine-1-phosphate (S1P) in patients with acne vulgaris and compare them to healthy controls. The goal is to explore their possible role in the pathogenesis and severity of acne. Blood samples will be collected from participants, and quantitative analysis will be performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
For Case Group
Both males and females aged 15-40 years.
Mild, Moderate, severe and very severe cases will be included. 5
Presence of any dermatological condition other than acne vulgaris (for cases).
Use of systemic or topical treatment such as isotretinoin or antibiotics within the last 3 months.
Pregnancy or lactation.
History of lipid-lowering therapy or supplements affecting ceramide or sphingolipid metabolism.