Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses. Recent evidence suggests a possible link between severe periodontitis and cardiovascular diseases through shared inflammatory pathways.
The PAROCAR study aims to evaluate the association between generalized periodontitis (stages 3 and 4, 2017 Chicago Classification) and arterial stiffness measured by pulse wave velocity (PWV), compared to matched controls without periodontitis, adjusted for conventional cardiovascular risk factors.
Age 40-69 years
Minimum of 12 teeth (3 per quadrant)
Written informed consent Exposed group: generalized periodontitis stage 3 or 4 (Chicago 2017 Classification) Non-exposed group: healthy periodontium
Patients diagnosed with diabetes,
Patients diagnosed with hypertension or with a history of severe cardiovascular disease,
Patients diagnosed with familial hypercholesterolaemia,
Patients with a medical history or current condition that, in the investigator's opinion, is likely to interfere with the study results,
Nantes University Hospital
Lead sponsor
French Interregional Group of Clinical Research and Innovation
Collaborator
Université de Nantes
Collaborator
Axelife company
Collaborator