Juxta-renal abdominal aortic aneurysms (AAA) are challenging to treat with standard endovascular techniques (EVAR) due to their proximity to the renal arteries. Open surgical repair continues to be used in patients unsuitable for EVAR but carries a high risk of acute kidney injury (AKI), up to 24%. Postoperative AKI is a strong predictor of both short- and long-term cardiovascular mortality. The KDIGO criteria are used to better define and stage AKI. Pharmacological prevention strategies have shown limited effectiveness, prompting interest in ischemic preconditioning (IPC). Remote IPC has shown mixed results in cardiac and vascular surgery, depending on patient risk and protocols used. Local IPC, applied directly near the renal arteries, has shown promising renal protection in animal models. However, this technique has never been clinically tested in humans. We propose here a randomized trial to assess the efficacy of local IPC before suprarenal aortic clamping during open repair of juxta-renal AAA to reduce postoperative AKI.
Patients aged 18-85 years
Patients with juxtarenal abdominal aortic aneurysms scheduled for open surgery
Patients with juxtarenal abdominal aortic aneurysms, which require suprarenal aortic cross clamping
Patients with juxtarenal abdominal aortic aneurysms, which are of atheromatous etiology or which developed after aortic dissection
Patients dependent from dialysis
Patients with aortic aneurysms, which require reconstruction of the visceral arteries
Patients with aortic aneurysms, which require supra-visceral aortic cross clamping
Patients with wall thrombus or calcification of inter- and suprarenal aorta