Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorHospital Nord
About this trial
Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.
Eligibility criteria
Qualifiers
Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.
Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.
Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.
Disqualifiers
Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) < 30%.
Severe right ventricular dysfunction defined by TAPSE < 12 mm.
Cardiac arrhythmia or atrial fibrillation.
Abdominal compartment syndrome.
Trial design
Treatments tested in this trial
- Fluid bolus administration
Treatment groups
205 Participants
are divided into 1 treatment groupSponsors and collaborators
Hospital Nord
Lead sponsor
Aix Marseille Université
Sponsor institution
Source ClinicalTrials.gov