To assess quantitatively the evolution over time of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia
Adult patients ≥ 18 years
Hypotonic hyponatremia
glucose-corrected plasma sodium <130 mmol/l
serum osmolality <280 mosmol/kg or lack of signs of non-hypotonic hyponatremia
Signs of extracellular volume expansion
Patients with liver cirrhosis and severe liver damage AST/ALT>3xULN, AP>6xULN, Bilirubin ≥ 3mg/dl
Patients with heart failure
Patients on dialysis and/or patients with oliguric renal impairment and plasma creatinine ≥ 3mg/dl