About this trial
In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether FDG-PET is able to identify those at increased risk of PVE relapse.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patient aged 18 or over;
Have a prosthetic valve implanted surgically or by catheter for at least 3 months;
Presenting a definite IE on a prosthetic valve (ESC definition in force);
Having benefited from an FDG-PET examination for diagnostic purposes as part of the treatment revealing pathological hyperuptake at the level of the prosthetic valve AND carried out <15 days after the start of antibiotic therapy for infective endocarditis;
Disqualifiers
Patient under legal protection, guardianship or curators;
Pregnancy, breastfeeding;
Patient not affiliated to a health insurance scheme or not a beneficiary of a social security scheme;
Simultaneous participation in a study on FDG-PET;
Trial design
Single group
Treatments tested in this trial
FDG-PET at the end of treatment for IE
RadiationFDG-PET at the end of treatment for IE in patients with a prosthetic valve
Treatment groups
Trial outcomes
Primary outcomes
Presence of pathological uptake on the prosthetic valve on FDG-PET
Presence of pathological uptake on the prosthetic valve on FDG-PET performed after the recommended duration of curative antibiotic treatment
Secondary outcomes
Evolution of the FDG uptake intensity on the prosthetic valve by FDG-PET
by comparing the FDG uptake intensity on the prosthetic valve between initial and at the end of curative antibiotic treatment FDG-PET
Presence of the intensity of extracardiac uptake on the FDG-PET at the end of curative antibiotic treatment in patients presenting with pathological extracardiac uptake on the initial FDG-PET
by comparing the intensity of extracardiac uptake between FDG-PET initial and at the end of curative antibiotic treatment
Evolution of the intensity of extracardiac uptake on the FDG-PET at the end of curative antibiotic treatment in patients presenting with pathological extracardiac uptake on the initial FDG-PET
by comparing the intensity of extracardiac uptake between FDG-PET initial and at the end of curative antibiotic treatment
Relapse of endocarditis defined by the same location and the same microorganism within 6 months
Sponsors and contacts
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