Examining the Circadian Timing Effects of the Hypotensive Response to Exercise

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-39
SponsorFreda Patterson

About this trial

The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns. A single exercise session can lower blood pressure for up to 24 hours, but it is not fully understood how the time-of-day for exercise affects this response. The main question this study aims to answer is:

• When the same participant exercises at different times of day (morning, afternoon, or evening), how does this affect the participant's blood pressure over the next 24 hours?

Participants will:

* Undergo an in-lab assessment of individual biological rhythm that will indicate the clock-time for an individual's biological night * Complete 3 supervised treadmill exercise sessions

* 1 in the biological morning (biological night + 10 hours) * 1 in the biological afternoon (biological night + 15 hours) * 1 in the biological evening (biological night + 20 hours) * Complete a 24-hour blood pressure assessment before and after each exercise session

Eligibility criteria

Qualifiers

18-39 Years old

Resting blood pressure greater than or equal to 120/80 mmHg or less than 140/90 mmHg

Disqualifiers

Diagnosis or history of chronic or autoimmune disease (i.e., cardiovascular, metabolic, renal, endocrine, cancer)

Diagnosis or history of sleep disorder (i.e., obstructive sleep apnea, insomnia, restless leg syndrome)

Alcohol or drug dependence

Elevated risk for sleep disorders

Trial design

Treatments tested in this trial

  • Exercise

Treatment groups

30 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Freda Patterson

Lead sponsor

University of Delaware

Sponsor institution