The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery.
This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes.
The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.
Gestational age: 24-40 weeks
Cases: Diagnosis of severe preeclampsia
Control: Normal blood pressure
Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure).
Clinical conditions that could hinder the results (diarrhea, vomit)
Recent use of bicarbonate
Single group
Arterial Blood gases
Diagnostic testDetermination of Excess Base in arterial blood gases before delivery / termination of pregnancy
Value of excess base
Total measure of excess base measured by gasometry in an arterial blood sample
Hypertensive crisis
Elevation of the blood pressure above 160 (systolic) and 110 (diastolic).
Lactate
Concentration of lactate measured by gasometry in a sample of arterial blood.
Bicarbonate
Concentration of bicarbonate measured by gasometry in arterial blood gases
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