Exercise & Brain Energetics in PD
ConditionParkinson Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-80
SponsorPacific Parkinson's Research Centre
About this trial
There is increasing evidence that the usage and delivery of energy to the brain, known as brain energetics, is altered in people with Parkinson's disease (PD). This project will explore whether exercise has a positive impact on brain energetics using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) brain scanning in PD subjects.
PD subjects will be scanned before and after a supervised exercise program to investigate the effect of exercise on brain energetics. In a separate study, the investigators will also scan healthy volunteers to compare brain energetics in the healthy brain with the brain energetics data in PD subjects acquired in this study.
Eligibility criteria
Qualifiers
Idiopathic PD according to UK Brain Bank criteria (modified to permit inclusion of subjects with a family history)
Mild to moderate Parkinsonism (Hoehn & Yahr stages I-III)
Currently exercise less than 120 minutes per week (PD non-exercisers)
Disqualifiers
atypical Parkinson syndrome (progressive supranuclear palsy, multiple system atrophy, drug-induced etc.);
significant osteoporosis or arthritis;
history of cancer within 5 years of study participation;
high dose of radiation from other procedures within the year;
Trial design
Treatments tested in this trial
- Active exercise
- Passive exercise
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Pacific Parkinson's Research Centre
Lead sponsor
Natural Sciences and Engineering Research Council, Canada
Collaborator
Source ClinicalTrials.gov