Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55+
SponsorVA Office of Research and Development

About this trial

The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.

Eligibility criteria

Qualifiers

Age > 55 years

Diagnosis of stage 3-4 CKD or an eGFR of <45 mL/min/1.73m2

Disqualifiers

Cardiovascular risk: Poorly controlled hypertension (>160/100)

Coronary event in past 6 months

Class III or IV CHF

symptomatic angina at rest or during exercise

Trial design

Treatments tested in this trial

  • Exercise

Treatment groups

250 Participants
are divided into 2 treatment groups