Exercise Intolerance in Heart Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age21+
SponsorJohns Hopkins University
About this trial
The investigators are studying whether metabolic abnormalities in cardiac and skeletal muscle in patients with heart failure with preserved ejection fraction (HFpEF) are associated with debilitating exercise intolerance.
Eligibility criteria
Qualifiers
Patients of either gender who are greater than 21 years of age (no upper age limit),
Permission of patient's clinical attending physician,
Previous clinical diagnosis of HF with current New York Heart Association (NYHA) Class II-III symptoms for at least 1 month,
Left ventricular ejection fraction (EF) >50% by echocardiography, MRI, CT or x-ray or nuclear ventriculography within prior 12 months,
Disqualifiers
Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent,
Contraindications to MRI such as implanted metallic objects (pre-existing cardiac pacemakers, cerebral clips) or indwelling metallic projectiles,
Significant valvular abnormalities,
Pregnant women (women of childbearing potential will undergo blood or urine pregnancy testing),
Trial design
Treatments tested in this trial
- Not listed
Trial groups
130 Participants
are grouped into 4 trial groupsSponsors and collaborators
Johns Hopkins University
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov