Exercise to Improve Sleep in Parkinson's Disease

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40+
SponsorMcGill University

About this trial

This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with Parkinson's disease (PD). Furthermore, the project will investigate whether the potential positive exercise-induced changes in sleep are associated with improvements in different quality of life (QoL)-related aspects. Participants will perform either cardiovascular training (CT), resistance training (RT), multimodal training (MT), or will be allocated to a control condition (i.e., waiting list - CON) for 12 weeks. Training will be performed three times/week. The assessments will be conducted at baseline, post-intervention, and follow-up (i.e. 8 weeks after the intervention) by assessors blinded to the participants' group allocation.

Eligibility criteria

Qualifiers

Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn & Yahr Scale stages 0.5-3.5);

On a stable dosage of medication during the previous month;

Having poor sleep quality defined as a score > 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality;

Disqualifiers

Having atypical parkinsonism, dementia, stroke, or any other neurological condition;

Presenting severe untreated obstructive sleep apnea (OSA);

Having a Montreal Cognitive Assessment (MoCA) score <18

Having a Beck Depression Inventory score >31;

Trial design

Treatments tested in this trial

  • Cardiovascular training (CT)
  • Resistance training (RT)
  • Multimodal training (MT)

Treatment groups

150 Participants
are divided into 4 treatment groups

Sponsors and collaborators

McGill University

Lead sponsor

Jewish Rehabilitation Hospital

Collaborator

The Memory Lab

Collaborator

The Human Brain Control of Locomotion Lab (HBCL)

Collaborator

The Cummings Centre

Collaborator

Canadian Institutes of Health Research (CIHR)

Collaborator