About this trial
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.
Eligibility criteria
Qualifiers
Women
Postmenopausal (50-75 yrs.)
Obese (BMI 30-50 kg/m2)
Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
Disqualifiers
Engaging in purposeful resistance training or endurance training (> 20min/day, > 2 days/week)
Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
Type 1 or type 2 diabetes
Medical problems in which exercise is contraindicated, such as chronic infections
Trial design
Treatments tested in this trial
- Resistance Exercise
- Endurance Exercise
Treatment groups
Sponsors and collaborators
Florida State University
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Pennington Biomedical Research Center
Collaborator
University of Arkansas
Collaborator