Exploratory Study of EBV DNA Titre Clearance Whilst on Proton Beam Therapy
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age8-30
SponsorThe Christie NHS Foundation Trust
How does plasma Epstein-Barr Virus (EBV) DNA level change during definitive radiation therapy for nasopharyngeal carcinoma (NPC) in the teenage and young adult cohort and does it correlate with outcomes?
Children and young adults (8-30 years old)
Pathologically confirmed EBV-positive nasopharyngeal carcinoma
Stage I-IVA (AJCC 8th Edition)
Planned to commence curative-intent radiation therapy
Recurrent NPC
Concurrent or previously treated EBV-associated malignancy
Prior radiation therapy
Contraindications to MRI