Explore the Impacts of Theta Burst Stimulation Over the Right Inferior Frontal Gyrus in Autism Spectrum Disorder: Combination of Clinical Symptoms, Neuropsychological Function and MRI

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age8-30
SponsorChang Gung Memorial Hospital

About this trial

Exploring the therapeutic efficacy of Theta Burst Stimulation (TBS) over the right inferior frontal gyrus (RIFG) in autism, including changes in core symptoms, adaptive functioning, neuropsychological performance, and neurophysiological signals.

Eligibility criteria

Qualifiers

Participants aged 8 to 30 years with a clinical diagnosis of Autism Spectrum Disorder (ASD), confirmed by the ADOS-2 (Autism Diagnostic Observation Schedule, Second Edition).

DSM-5 severity level of ASD: level 1 or level 2

Participants who have been on a stable treatment regimen prior to the study, or those for whom conventional treatments have been assessed as ineffective by a physician, or those who decline conventional treatment.

A score of ≥ 15 on the University of California Brief Assessment of Capacity to Consent (UBACC) and demonstrated understanding of study aims and risks via the teach-back method.

Disqualifiers

Previous or current severe neurological disorders, especially epilepsy, visual or auditory impairments

Previous or current severe systemic diseases such as cardiovascular disease, diabetes or hypertension

Previous or current severe brain injury

Implementation of metal materials such as a pacemaker or medication pump

Trial design

Treatments tested in this trial

  • intermittent theta burst stimulation

Treatment groups

60 Participants
are divided into 2 treatment groups

Sponsors and collaborators