This is an observational study of patients with lupus nephritis aiming to find biomarkers that can predict patients' response to immunosuppressants. We planed to collect 100 lupus nephritis patients' peripheral blood,kidney tissues and urine before and after treatment (mycophenolate mofetil or cyclophosphamide, in combination with glucocorticoids). Then multi omics analysis, including single cell RNA-seq, ATAC-seq and CITE-seq, will be performed to find new biomarkers for patients' response and prognosis.
Age between 16-60 years.
Fulfilling the 2012 SLICC classification for SLE.
Renal biopsy pathology was clearly classified as III \ IV \ V+III \ V+IV within 6 months.
Renal biopsy reveals active disease.
Other concomitant connective tissue diseases or autoimmune diseases.
Neuropsychiatric lupus, alveolar hemorrhage, retinal lesions, pulmonary arterial hypertension, or other severe organ involvement.
Pregnant or lactating women.
Current infections that require antibiotic or antiviral treatment.