FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorCentral Hospital, Nancy, France

About this trial

The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.

Eligibility criteria

Qualifiers

aged over 18

Person who participated in the Stanislas Cohort

Person affiliated to a social security scheme or beneficiary of such a scheme

Person having received complete information on the organization of the research and having signed an informed consent

Disqualifiers

Persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric treatment under Articles L. 3212-1 and L. 3213-1

Pregnant woman, parturient or nursing mother

Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)

Person of full age unable to express consent

Trial design

Treatments tested in this trial

  • Blood and urine samples
  • Blood samples
  • Cardiovascular assessment
  • Dietary intake
  • Anthropometric parameters
  • Hemodynamic parameters
  • Hemodynamic parameters
  • Hemodynamic parameters
  • Hemodynamic parameters
  • Assessment of compliance with antihypertensive treatments for treated participants
  • Ambulatory 24 hours measurment of blood pressure
  • 24 hours urinary collection
  • General questionnaires
  • Women specific questionnaire
  • Women specific questionnaire
  • NYHA dyspnea questionnaire
  • Anxiety questionnaire
  • Epworth Sleepiness Scale
  • A questionnaire on the "perception of the management of cardiovascular risk factors"
  • A questionnaire on eating behaviors
  • A questionnaire on eating habits to determine consumer profiles
  • A questionnaire on food supplements use
  • SARS-CoV-2 Infection Questionnaire
  • Instantaneous expired air analysis
  • Capillary sampling

Treatment groups

3,000 Participants
are divided into 1 treatment group