Fatty Acid Modulation of Brain Function in Older Adults
ConditionAging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-75
SponsorUniversity of Vermont
About this trial
In this crossover study, the investigtors will administer two experimental diets in a random order for one week, and each experimental diet will be preceded by a one-week, low fat control diet for a total four-week study period. The goal is to study how the fatty acid content of the diet affects brain functioning in healthy adults aged 65-75 years. One experimental diet will have a high palmitic acid (PA)/oleic acid (OA) ratio (HPA), typical of the North American diet. The other experimental diet will have a low PA/OA ratio (HOA), typical of the Mediterranean Diet. All allowed food and drink (except water) will be provided by the investigative team, and compliance will be enhanced by constant, intense dietary surveillance by a registered dietitian.
Eligibility criteria
Qualifiers
Men and women age range 65-75 years
Normal cognition (see Research Strategy for details on cognitive assessments)
"Healthy" (body mass index (BMI) of 20-40 kg/m2)
Disqualifiers
Significant cognitive or behavioral impairment (see Research Strategy for testing and exclusions) or pharmacological treatment for this (e.g. antipsychotics, anxiolytics, and sedative medications).
Hormone replacement therapy, past 3 months.
Hyper-androgenic condition.
HbA1C≥7.5% and or Fasting plasma glucose concentration ≥130 mg/dL.
Trial design
Treatments tested in this trial
- High Oleic Acid Diet
- High Palmitic Acid Diet
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov