FCV Vs VCV in Obstructive and Asthmatic Patients
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-100
SponsorErasmus Medical Center
About this trial
The goal of this physiological pilot study with a randomized crossover design is to study the effect of Flow-controlled ventilation (FCV) on the minute volume compared to Volume-controlled ventilation (VCV) in intubated patients with an exacerbation of their asthma or COPD.
Our hypothesis is that FCV will results in a lower minute volume compared to VCV in this patient category.
Patients will be randomized between two ventilation sequences, namely 90 minutes of FCV followed by 90 minutes of VCV or vice versa.
Eligibility criteria
Qualifiers
18 years or older;
Provided written informed consent;
Undergoing controlled mechanical ventilation via an endotracheal tube;
Reason for intubation being exacerbation of asthma or COPD;
Disqualifiers
Severe sputum stasis or production requiring frequent bronchial suctioning (more than 5 times per nurse shift)
Untreated pneumothorax (i.e. no pleural drainage)
Hemodynamic instability defined as a mean arterial pressure below 60mmHg not responding to fluids and/or vasopressors or a noradrenalin dose >0.5mcrg/kg/min
High (>15 mmHg) or instable (an increase in sedation or osmotherapy is required) intracranial pressure
Trial design
Treatments tested in this trial
- FCV
Treatment groups
10 Participants
are divided into 2 treatment groupsSponsors and collaborators
Erasmus Medical Center
Lead sponsor
Maasstad Hospital
Collaborator
Source ClinicalTrials.gov