Feasibility of CBCT-Guided Online Adaptive Radiotherapy (FASCINATE)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorThe Netherlands Cancer Institute
About this trial
The accuracy of radiotherapy can be increased by correcting for geometric uncertainties and changes between radiotherapy fractions. These corrections are currently done with online adaptive treatment on a specialized linear accelerator (linac) for a small subset of patients. However, patients currently treated on a standard linac could also benefit from online adaptive radiotherapy. The objective is to determine the feasibility of online CBCT-guided adaptive radiation therapy on a standard Elekta linac.
Eligibility criteria
Qualifiers
Patient, age ≥ 18 years, referred for a radiotherapy schedule as described in one of the cohorts.
WHO performance score 0-3.
Provision of signed, written and dated IC prior to any study specific procedures.
Accepted for radiotherapy of the prostate and pelvic lymph node areas.
Disqualifiers
Patients who are pregnant.
Patients with a medical condition that severely compromises CBCT image quality (mainly hip prostheses).
Severe lower urinary tract symptoms that could make the longer treatment time problematic (according to judgement of treating physician).
Patients with a medical condition that severely compromises CBCT image quality (mainly hip prostheses).
Trial design
Treatments tested in this trial
- online CBCT-guided adaptive radiation therapy using a new software
Treatment groups
100 Participants
are divided into 5 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov