This clinical trial will investigate the effects of capsules containing stool from healthy donors, called fecal microbial transplant (FMT), in rheumatoid arthritis patients.
18-years old or older
RA diagnosis by ACR/EULAR criteria [26]
Positive for the RA-associated antibodies, anti-citrullinated protein/peptide antibodies (ACPA) and/or rheumatoid factor (RF)
Stable RA therapy > 6 months
Pregnant or breastfeeding
Current or recent [in the last 60 days] exposure to high dose oral (>30 mg of prednisone daily or equivalent), IV corticosteroids, biologic therapies or JAKi.
Patients who require inhaled steroids or local steroid injections are not excluded from the study
Has a diagnosis of immunodeficiency (HIV, transplantation, or autoimmune disease other than RA requiring immunosuppressive therapies), or currently receiving systemic steroid therapy (>10 mg prednisone daily or equivalent)
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead sponsor
St. Joseph's Health Care London
Collaborator