Hypotheses:
We hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate.
Aims:
* To determine if the use of female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm in the IUI will show higher clinical pregnancy rate (CPR). Clinical pregnancy rate as determined by a positive serum beta-hCG test result and at least one gestational sac at 6 weeks gestation * To assess the safety of female PRP co-incubation with husband's sperm in the IUI.
Primary outcome:
To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing IUI with female PRP co-incubation with husband's sperm group and non-PRP group.
Secondary outcomes:
* To evaluate the safeness between the female PRP co-incubation with husband's sperm in the IUI group and non-PRP group, including potential infection rate or other complications such as ectopic pregnancy and molar pregnancy * To evaluate the sperm quality between the intervention group and control group
Data analysis: Data analysis will be performed using Statistical Packages of Social Sciences for Windows
Expected results: The investigators expect that a 50% pregnancy rate increase after the application of female PRP co-incubation with husband's sperm in the IUI
Patients undergoing IUI cycles
Infertility patients aged >18 years old and < 42 years old
BMI <30 kg/m2
No sexually transmitted diseases, AIDS, syphilis and other infectious disease
Concurrent administration of other agents such as prednisolone, intravenous immunoglobulin, or G-CSF
Administration of anticoagulants or NSAIDs at least 7 days before PRP infuse
Drug addiction
Urinary tract infection