Fermented Foods and Bowel Health in SCI

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorOhio State University

About this trial

The goal of this clinical trial is to learn whether consuming a high fermented food diet improves bowel function and gut health in adults with chronic spinal cord injury (SCI). The study will also evaluate the feasibility and tolerability of consuming fermented foods daily for 10 weeks. The main questions it aims to answer are:

1. Does a high fermented food diet improve neurogenic bowel dysfunction symptoms and colonic transit in adults with SCI? 2. Does fermented food intake change gut microbiome composition, short-chain fatty acid production, and intestinal inflammation?

Researchers will compare a high fermented food diet to a control diet to evaluate effects on bowel health and gut microbiome outcomes.

Participants will:

* Consume study foods daily for 10 weeks * Attend 2 in-person study visits * Collect stool samples at home and ship them overnight to the research team using provided collection kits and prepaid shipping materials * Complete bowel health questionnaires and dietary recalls * Undergo Sitz marker testing with abdominal X-rays to assess colonic transit * Participate in biweekly monitoring contacts throughout the study period

Eligibility criteria

Qualifiers

Adults aged 18-70 years

At least 1 year post-onset of spinal cord injury, consistent with chronic spinal cord injury

Traumatic spinal cord injury involving cervical or thoracic levels

American Spinal Injury Association Impairment Scale classification A-D

Disqualifiers

Antibiotic use within the past 4 weeks

Active gastrointestinal disease, including Crohn's disease, ulcerative colitis, celiac disease, or gastrointestinal obstruction

Current intake of probiotics or fermented foods exceeding 3 servings per day

Pregnancy or breastfeeding

Trial design

Treatments tested in this trial

  • fermented foods
  • Control diet
  • Sitz Marker Test

Treatment groups

44 Participants
are divided into 2 treatment groups

Sponsors and collaborators