About this trial
The goal of this clinical trial is to learn whether different natural approaches to preparing the uterus for frozen embryo transfer (FET) can improve pregnancy success in women undergoing in vitro fertilization (IVF) treatment.
The main questions it aims to answer are:
1. Is a completely natural menstrual cycle more successful than a natural cycle in which ovulation is triggered with medication when preparing for frozen embryo transfer? 2. Does taking a medication called letrozole at the beginning of the cycle improve pregnancy success compared to not taking it?
Researchers will compare four different approaches to see which one results in the highest chance of achieving a clinical pregnancy, confirmed by ultrasound.
Participants will:
* Be randomly assigned to one of four groups * Undergo monitoring with ultrasound and blood hormone tests during their menstrual cycle * In some groups, take letrozole tablets for a few days early in the cycle * In some groups, receive a hormone injection to help control the timing of ovulation * Undergo frozen embryo transfer at the appropriate time * Receive standard hormonal support after embryo transfer * Researchers will compare four different approaches to see which one results in the highest chance of achieving a clinical pregnancy, confirmed by ultrasound.
Eligibility criteria
Qualifiers
Women aged 18 to 40 years
Regular menstrual cycles (26-35 days)
Scheduled for frozen embryo transfer (FET) in a natural menstrual cycle
Normal gynecological ultrasound findings without clinically significant uterine abnormalities
Disqualifiers
Use of preimplantation genetic testing (PGT) for the transferred embryo
Use of donor oocytes
Inadequate embryo survival after thawing, defined as loss of viability in more than 50% of blastomeres
Irregular menstrual cycles
Trial design
Treatments tested in this trial
- Letrozole (Aromatase Inhibitors)
- Choriogonadotropin alpha (r-hCG)
- Progesterone