fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

ConditionsPain, Postoperative Pain, Chronic Pain, Acute Surgical Injury Surgical Wound Cornea Injury Cornea Keratoconus

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age8-35

SponsorBoston Children's Hospital

About this trial

Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

Eligibility criteria

Qualifiers

Age 8-35 years

Clinical diagnosis of keratoconus and seeking CXL treatment

English speaking ability sufficient to comprehend consent with parental assistance

MRI compatible

Disqualifiers

Claustrophobic

Weight > 285 lbs (weight limit of the MRI table)

Magnetic implants or metal-containing tattoos on their chest or above

Pregnancy

Trial design

Treatments tested in this trial

Not listed

Trial groups

60 Participants

are grouped into 2 trial groups

Sponsors and collaborators

Boston Children's Hospital

Lead sponsor

Source ClinicalTrials.gov