About this trial
This study addresses a critical gap in the care of older women with breast cancer, a population often underrepresented in clinical research despite their increased vulnerability to treatment-related complications. By examining the relationship between frailty and health-related quality of life (QOL), the study aims to provide evidence-based insights into how geriatric assessments can guide personalized treatment decisions, ensuring that therapeutic benefits outweigh risks. Given that older adults prioritize QOL over survival gains, understanding the impact of frailty on their well-being can help clinicians optimize care plans, reduce adverse outcomes, and improve overall patient-centered outcomes. The findings may also inform the integration of routine geriatric assessments in oncology practice, ultimately enhancing the management of older cancer patients in resource-limited settings like Egypt.
Eligibility criteria
Qualifiers
Females aged 60 years and older
Newly diagnosed with pathologically proven breast invasive ductal or lobular carcinoma
Disqualifiers
History of cognitive impairment or psychiatric disorders
Delirium during assessment using the Confusion Assessment Method (CAM test)
Initiation of chemotherapy before the baseline assessment
Severe hearing or visual impairment preventing completion of assessment
Trial design
Treatments tested in this trial
- Comprehensive geriatric assessment
- European Organization for Research and Treatment-Quality of life questionnaire
- Clinical Frailty Scale