Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.
histologically verified lung cancer (small-cell and non-small cell lung cancer)
referred for radiotherapy with curative intent
radiation dose of 60-66 Gy given in 2-Gy fractions, other dose levels and fractionation schedules accepted, as per site standard
concurrent chemotherapy is accepted
concurrent immunotherapy
previous radiotherapy to the thorax
other uncontrolled malignancies; any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol
University of Aarhus
Lead sponsor
Aarhus University Hospital
Sponsor institution
Westmead and Blacktown Hospital, Sydney West Radiation Oncology Network, Sydney, Australia
Collaborator
Aarhus University Hospital
Collaborator
South Eastern Sydney Local Health District
Collaborator
The University of New South Wales
Collaborator
Northern NSW Local Health District, NSW Australia
Collaborator