About this trial
The G8 screening tool is widely recommended for the identification of frailty in older adults with cancer. However, prospective validation data in the Portuguese population are currently lacking.
This prospective observational study aims to evaluate the diagnostic performance of the G8 screening tool compared with a Comprehensive Geriatric Assessment (CGA) in older adults with cancer. Patients aged ≥70 years with solid tumors will be assessed using both the G8 screening tool and a multidimensional CGA. Frailty will be defined as impairment in at least one CGA domain. The performance of the G8 will be evaluated in terms of sensitivity, specificity, and area under the receiver operating characteristic curve.
This study aims to provide the first prospective validation of the G8 screening tool in Portuguese older adults with cancer and to support its implementation in clinical practice.
Eligibility criteria
Qualifiers
Age ≥70 years;
Histologically confirmed solid malignancy, regardless of tumor site or stage;
Referral to a multidisciplinary geriatric oncology consultation;
Consideration for or planned systemic anticancer treatment;
Disqualifiers
Age <70 years;
Diagnosis of hematological malignancy (e.g., leukemia, lymphoma, multiple myeloma);
Severe cognitive impairment precluding completion of assessment tools without available caregiver support;
Clinical instability or acute condition preventing data collection (e.g., hospitalization for acute complication);
Trial design
Treatments tested in this trial
- G8 Screening Tool
- Comprehensive Geriatric Assessment