The aim of this study is to:
1. Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls. 2. Evaluation expression of tissue Gasdermin D using immunehistochemstry techniques in patients with generalized vitiligo after narrow band ultraviolet B therapy. 3. Determine whether there is a relationship between Gasdermin D levels and disease duration and involved body surface area (VISA) in vitiligo patients.
Patients with stable vitiligo of 6 months duration,
Both sex and ages(10-75)
pregnancy,
lactation,
patients under or previous phototherapy,
patients on other immunosuppressives,