Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-120
SponsorNational Institute on Aging (NIA)
About this trial
Background:
\- Biomarkers are substances in people s blood and tissues. They help researchers understand diseases and signs of aging. Scientists want to do more research on biomarkers to find ways to improve quality of life in old age.
Objective:
\- To learn more about biomarkers and their relationship to aging.
Eligibility:
\- Adults at least 20 years old who weigh at least 110 pounds and have a body mass index below 30. They must agree that their genetic samples can be collected, studied, and stored.
Design:
* Participants will be screened with medical history, physical exam, EKG and blood and urine tests. * Participants will have 3-day visits. They will return every 2 years. * All visits include: * Blood and urine collection * Physical performance tests * Health questionnaires * Memory and problem-solving tests * Magnetic Resonance Imaging (MRI) and Computerized Tomography (CT) scans. * Muscle metabolism/ exercise tests * Taste strips * Muscle and/or skin biopsies/ red light therapy * Retinal imaging/ eye tracking * Sleep study * ODD visits also include: * Cytapheresis * Bone marrow aspirate * EVEN visits also include: * Hyperglycemic CLAMP * Lumbar Puncture (LP) * Continuous Glucose Monitor (CGM)
Eligibility criteria
Qualifiers
Since the study of gene expression and epigenetic regulation are essential aims of GESTALT, all participants are required to consent to DNA/RNA testing and storage at all visits. Participants that refuse genetic testing and storage will not be eligible to participate or to continue to participate in the study.
Age greater than or equal to 20 years of age.
Are willing to return every 2 years for study visit procedures.
Agree to genetic (DNA/RNA) sample collection, analysis and storage.
Disqualifiers
HIV virus infection (all groups).
Hepatitis B or C (all groups).
Active syphilis, gonorrhea or TB requiring treatment (all groups).
WBC <3,000 or > 12,000/k/microL (only Healthy group).
Trial design
Treatments tested in this trial
- Not listed
Trial groups
900 Participants
are grouped into 3 trial groupsSponsors and collaborators
Source ClinicalTrials.gov