Genetic Basis of Immunodeficiency
ConditionSevere Combined Immunodeficiency
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age6-99
SponsorNational Heart, Lung, and Blood Institute (NHLBI)
About this trial
This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID).
Patients with immunodeficiencies may be eligible for this study. Candidates include:
* Patients with diminished numbers of T cells or NK cells or both, or * Patients with normal T cell and NK cell numbers but diminished T cell, B cell, or NK cell function.
Relatives of patients will also be studied.
Participants will have blood samples collected for genetic analysis in studies related to SCID at the National Institutes of Health and other institutions.
Eligibility criteria
Qualifiers
Patients (index cases): 6 months of age and older
Siblings: 6 months of age and older
Non-sibling relatives (biological parent, aunt, uncle or grandparent): 18 years or older
Disqualifiers
Patients with a known diagnosis
Patients with a particular immunological phenotype that is not of interest to the research conducted under this study.
Pregnancy or lactation
Adults with current decisional impairment
Trial design
Treatments tested in this trial
- Not listed
Trial groups
100 Participants
are grouped into 3 trial groupsSponsors and collaborators
Source ClinicalTrials.gov