Genetic Causes of Discrepant Clinic in Monogenic Twins
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorUniversity Hospital Tuebingen
About this trial
In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate of the subjects included in the study.
Eligibility criteria
Qualifiers
Twin pair monozygotic clinically (phenotypic) discordant twins
Unclear diagnosis
Suspected (mono-)genetic cause of the disease in one twin
Disqualifiers
Missing informed consent of both twin/ legal representative
No distinct phenotype
Trial design
Treatments tested in this trial
- NGS Diagnostic
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov