Genetic Susceptibility to Listeriosis
ConditionListeriosis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorInstitut Pasteur
About this trial
Listeriosis is a rare, severe foodborne infection, responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and / or patients with comorbidities, with a deficit of innate or cellular immunity. Pregnancy is also a risk factor.
The Multicentric Observational NAtional Analysis of Listeriosis and Listeria (MONALISA) is an ongoing national case-control prospective study on listeriosis implemented since 2009 to study risk and prognosis factors for listeriosis. In this cohort, which enrolled 902 patients on 1 August 2014, 7% of patients with neurolisteriosis are under 40 years of age and have no identified risk factor. Genetic susceptibility is suspected in these patients. Genetic susceptibility could also explain the inconstant development of a neurolisteriosis or fetal infection, as well as the particular severity of some infections (death, foetal loss, neurological sequelae).
The aim of the study is to identify genetic susceptibility to Listeriosis.
Eligibility criteria
Qualifiers
Microbiologically documented Listeriosis (either a severe form of listeriosis, or an atypical form of listeriosis, or less than 40 years old and without any co-morbidity identified)
Affiliated or beneficiary of a social security system
Informed and written consent
defined as father, mother, brother (s), sister (s), child (ren), grandparent (s), uncle (s), aunt (s), cousin (s), nephew (s), niece (s).
Disqualifiers
Inability to consent
Trial design
Treatments tested in this trial
- Human biological samples
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Institut Pasteur
Lead sponsor
Icahn School of Medicine at Mount Sinai
Collaborator
Source ClinicalTrials.gov