Genetic Variants Associated With the Risk of Gall Stones and Cirrhosis.
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorInstitute of Liver and Biliary Sciences, India
About this trial
Gall stone disease is more common in patients with cirrhosis. This association has been well established in different studies. Among the various factors which predispose a patient with gall stone disease to have associated liver cirrhosis, genetics also plays an important role.
This study aims to do a genetic panel-based analysis of genes which are involved in cholestasis to find any association between liver cirrhosis and gall stone disease.
Patients with history of gall stone or history of cholecystectomy done for gall stone disease will be evaluated for the presence of liver cirrhosis by fibroscan and ultrasonography. Those patients with cirrhosis and without cirrhosis will undergo a panel based genetic test for the common cholestasis genes and multivariate analysis will be done for variants associated with lithogenesis and cirrhosis.
Eligibility criteria
Qualifiers
Patients > 18 years of age.
Who has a GSD diagnosed by USG or have history of cholecystectomy for gall stone disease.
Who is a diagnosed case of cirrhosis by Fibroscan or USG (Cirrhosis including alcohol related cirrhosis, Hepatitis B, Hepatitis C, Wilsons disease, Hemochromatosis are excluded.
Disqualifiers
Patients who have haemolytic anaemia
Patients who do not consent for genetic study
Patients who has a diagnosed cause for liver disease, including alcohol related cirrhosis, Hepatitis B, Hepatitis C, Wilsons disease, Hemochromatosis.
Inability to provide informed consent.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
50 Participants
are grouped into 5 trial groupsSponsors and collaborators
Source ClinicalTrials.gov