About this trial
The goal of this clinical trial is to learn whether a preoperative genicular nerve block (GNB) can reduce pain after knee replacement surgery in adults with knee osteoarthritis (OA) undergoing total knee arthroplasty (TKA). It will also assess whether this treatment can reduce opioid use and improve recovery.
The main questions it aims to answer are:
* Does a preoperative GNB reduce pain during movement 24 hours after surgery compared with placebo? * Does it reduce opioid consumption and improve physical activity and functional outcomes after surgery?
Researchers will compare patients receiving a GNB to patients receiving a placebo injection to see if the nerve block improves postoperative pain and recovery.
Participants will:
* Be randomly assigned to receive either a GNB or a placebo injection before surgery * Undergo standard knee replacement surgery and postoperative care * Report pain levels at regular intervals after surgery * Complete questionnaires on function, quality of life, and recovery * Wear an activity monitor to measure physical activity after surgery * Attend follow-up assessments at 1 week, 1 month, and 3 months
Eligibility criteria
Qualifiers
Symptomatic knee OA grade II-IV according to the Kellgren-Lawrence classification system scheduled for primary total knee arthroplasty
American Society of Anesthesiologists (ASA) Physical Status grade I-III
Able to provide written informed consent
Able to undergo surgery under spinal anesthesia
Disqualifiers
Younger than 18 or older than 80 years
ASA physical status IV
Allergy to local anesthetics
Revision surgery
Trial design
Treatments tested in this trial
- Preoperative genicular nerve block (GNB)
- Placebo nerve block
Treatment groups
Sponsors and collaborators
Helse Møre og Romsdal HF
Lead sponsor
The Nordmøre and Romsdal Hospital Trust
Collaborator
St. Olavs Hospital
Collaborator
Oslo University Hospital
Collaborator