GEnomic Medicine in Kidney Transplantation Study
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorWestern Sydney Local Health District
About this trial
Investigator led, prospective, observational cohort study to detect genomic features which can predict outcomes following kidney transplantation.
1. Determine non-HLA genomic mismatches between donor-recipient pairs which impact kidney allograft survival following transplantation 2. Derive polygenic risk scores on pre-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction 3. Derive polygenic risk scores on post-transplant blood and/or kidney biopsy samples which predict kidney allograft dysfunction
Eligibility criteria
Qualifiers
able to provide informed consent (interpreter permitted) for enrolment
consenting to longitudinal follow up (can withdraw post enrolment)
consenting to provide samples for biobanking, including blood, urine, faecal and/or kidney biopsy tissue (collected prospectively, separate to routine care)
Disqualifiers
unable (or unwilling) to provide consent, or
have life-expectancy less than 6-months, or
have received a haematopoietic stem cell transplant in the past 5 years.
Trial design
Treatments tested in this trial
- Biomarker discovery and validation - with focus on genomic biomarkers
Treatment groups
1,000 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov