Background:
Heart disease is a leading cause of death in the United States. Healthy diet and exercise improve heart health. Some features of where a person lives can lead to stress and decrease chances for exercise. Researchers want to see how these factors may increase the risk of heart disease in women.
Objective:
To see if there are differences in stress levels between women who live in different parts of Washington, DC. Also, to see how these women use their neighborhoods for exercise.
Eligibility:
Healthy white or black females ages 19-45 who live in Washington, DC, who have access to a smartphone
Design:
Participants may stay at the NIH Clinical Center overnight for a 2-day visit.
Visit 1 will include:
Physical exam
Blood tests
Electrocardiogram: Electrodes on the participant s skin will measure heart activity.
PET/CT scan: Participants will get an injection. They will lie in a machine that takes pictures of the body.
Surveys
Body size measurements
Nutrition consultation
Blood vessel tests: This is measured with blood pressure cuffs, a device placed on the participant s fingertip, and a probe placed on the participant s neck.
Resting Energy Expenditure: Participants will breathe under a clear hood for 45 minutes.
Participants will be followed for about 2 weeks. They will wear a device on the wrist and carry a GPS device. Through a mobile app, they will answer short daily surveys on stress and exercise.
Visit 2-
Device return
Nutritional consultation
A healthy self-identified White female (i.e. self-identifies as White or of European descent) or healthy Black female (i.e. self-identifies as Black, African American, or of African descent)
Must be between 19 to 45 years of age
Must not have any chronic health condition (i.e.: cardiovascular, autoimmune, endocrinologic), or active infection
Must be living in Washington, DC
Pregnant or breast feeding
Physically unable to perform physical activity for any reason
Subject had weight changes greater than 20% over the past 3 months
Subject is obese by our measurements (BMI greater than or equal to 35.0 kg/m²)