GI Oxalate Absorption
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorUniversity of Chicago
About this trial
This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week.
For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.
Eligibility criteria
Qualifiers
Age 18-70
Previous history of Roux-en-Y gastric bypass
History of at least one calcium-based kidney stone after surgery
Pre-protocol urine oxalate above the lab normal range (50mg/day)
Disqualifiers
History of colon resection (partial or complete)
History of duodenal switch bowel surgery
History of ileal-jejunal bypass surgery
History of primarily uric acid, cysteine, or struvite stones
Trial design
Treatments tested in this trial
- Special low-oxalate diet followed by all-day visit to University of Chicago research clinic
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Chicago
Lead sponsor
University of Alabama at Birmingham
Collaborator
Source ClinicalTrials.gov