The aim of the GISE study is to confirm the MitraClip safety and improve the device effectiveness in a selected all comers ("more-comers") population with symptomatic severe mitral regurgitation undergoing/undergone Transcatheter Edge-to-Edge Repair (TEER) with MitraClip G4.
Left Ventricular End-Systolic Dimension <70 mm
Mitral Valve area > 4 cmq
Left ventricular ejection fraction ≥20%
NYHA functional class II, III, ambulatory IV
Significant right ventricular disfunction (TAPSE<15 mm and/or S'<8cm/s)
Systolic pulmonary artery > 70 mmHg with irreversible precapillary pulmonary hypertension
Severe TR Tricuspid valve regurgitation
Hemodynamic instability/NYHA IV