About this trial
Malignant pleural effusion remains a debilitating complication of end stage cancer, which can be greatly improved by the introduction of the indwelling tunneled pleural catheter (IPC). However, there is no standard of care regarding drainage and limited data on the utility of different drainage techniques. In addition, many patients develop discomfort and chest pain during drainage. The investigators propose to evaluate gravity drainage and suction drainage on quality of life measures and outcomes.
Eligibility criteria
Qualifiers
Clinical indications for placement of IPC for malignant pleural effusion
Clinically confident symptomatic malignant pleural effusion
Histocytological proof of pleural malignancy
Recurrent large pleural effusion in context of histologically proven cancer outside the pleural space
Disqualifiers
Recent (less than 60 days) thoracic surgery or chest trauma causing chronic pain
Pregnant or lactating mothers
Previous ipsilateral chemical pleurodesis
Current contralateral indwelling pleural catheter
Trial design
Treatments tested in this trial
- Vacuum-Based IPC
- Gravity-Based IPC
Treatment groups
Sponsors and collaborators
Johns Hopkins University
Lead sponsor
Rocket Medical plc
Collaborator
Swedish Medical Center
Collaborator
Medical University of South Carolina
Collaborator
University of Oxford
Collaborator
Vanderbilt University Medical Center
Collaborator
Northwest Community Healthcare
Collaborator