The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired glucose tolerance at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.
body mass index >18.5kg/m2 and <45.9kg/m2
impaired fasting glucose >/= 100mg/dL, </= 126mg/dL or impaired glucose tolerance on 75g oral glucose tolerance test (blood glucose 140 to 199mg/dL at two-hours)
pregnant, planning to become pregnant during the study, or breastfeeding
current diagnosis or history of type 1 or type 2 diabetes
use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
history of bariatric surgery