Handgrip Exercise Training and CKD
ConditionChronic Kidney Diseases
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-85
SponsorEmory University
About this trial
The purpose of this study is to find out if regular handgrip exercise performed at home can improve blood pressure at rest and during exercise in patients with chronic kidney disease (CKD).
This study is also intended to understand what causes an increase in blood pressure at rest and during exercise (i.e., increased adrenaline levels, or decreased ability of blood vessels to dilate). Patients with CKD will be recruited from primary care, Nephrology and other subspecialty Clinics throughout the Emory Healthcare System. Participants will attend 4 visits of 2-3 hours and 3 visits of 1-2 hours. The home exercise training will last for 8 weeks.
Eligibility criteria
Qualifiers
Patients with CKD (Stages IIIa and IV),
Ages 45-85 years who do not regularly exercise (defined as exercising less than 20 minutes twice per week), willing and able to cooperate with the protocol.
CKD Stages III and IV will be defined as reduction in estimated glomerular filtration rate (eGFR) to 15-59 cc/minute as calculated by the modified CKD-EPI equations.
Patients with CKD must have stable renal function (no greater than a 20% reduction in eGFR over the prior 3 months).
Disqualifiers
Severe CKD (eGFR<15 cc/minute)
Metabolic alkalosis (serum bicarbonate > 28 meq/L)
Ongoing drug or alcohol abuse
Diabetic neuropathy
Trial design
Treatments tested in this trial
- Isometric handgrip exercise training
- Sham Training
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Emory University
Lead sponsor
American Heart Association
Collaborator
Source ClinicalTrials.gov