About this trial
This study aims to learn what might predict heart problems (like sudden death from a fast heart rhythm or heart failure) in people with a genetic condition called hypertrophic cardiomyopathy (HCM). HCM causes the heart muscle to become thick, which can make the heart stiff and harder to work properly. It can also affect the heart's electrical system.
This study is looking to enroll patients that were previously part of a research project called "HCMR - Novel Predictors of Outcome in Hypertrophic Cardiomyopathy." The results of that study are still being reviewed, but they might show that people who had a substance called Gadolinium (MRI contrast or dye) collected in their heart muscle may have a higher risk for heart problems, including sudden cardiac death. This is called "late gadolinium enhancement" (LGE). This study is aiming to do follow-up imaging on those patients to better understand how LGE affects people with HCM.
Eligibility criteria
Qualifiers
Obstructive HCM
Males and females between 18 and 65 years of age
BMI < 35 kg/m2
Non-obstructive HCM
Disqualifiers
Paroxysmal atrial fibrillation or flutter documented prior to entry.
Paroxysmal or permanent atrial fibrillation requiring rhythm restoring treatment (eg, direct-current cardioversion, ablation procedure, or antiarrhythmic therapy) ≤6 months prior to entry. (This exclusion does not apply if atrial fibrillation has been treated with anticoagulation and adequately rate-controlled for >6 months.)
History of syncope or sustained ventricular tachyarrhythmia with exercise within 6 months prior to entry.
Pregnancy due to potential risk of gadolinium to the fetus
Trial design
Treatments tested in this trial
- None - observational study
Treatment groups
Sponsors and collaborators
Christopher Kramer
Lead sponsor
University of Virginia
Sponsor institution
Brigham and Women's Hospital
Collaborator
Mayo Clinic
Collaborator
Tufts Medical Center
Collaborator
Northwestern University
Collaborator
University of Michigan
Collaborator
The Cleveland Clinic
Collaborator
University Hospital Birmingham NHS Foundation Trust
Collaborator
Glenfield Hospital, Leicester
Collaborator
London Chest Hospital
Collaborator
Cytokinetics
Collaborator
Toronto General Hospital
Collaborator